Wound and Healing process

Wound and Healing process 150 150 Tony Guo

Wound and Healing process

  • A wound is a break or opening into the skin
    • Often occur because of accidents or injury
    • Range from minor scrapes to deep wounds involving bones, blood vessels, and nerves
  • Regeneration
    • Replacement of lost cells and tissues with cells of same type
  • Repair
    • Healing as a result of lost cells being replaced with connective tissue
    • More common than regeneration
    • More complex than regeneration
    • Occurs by primary, secondary, or tertiary intention


Primary intention

  • Includes 3 phases
    • Initial phase
      • Lasts 3 to 5 days
      • Edges of incision are aligned
      • Blood fills the incision area, which forms matrix for WBC migration
      • Acute inflammatory reaction occurs
    • Granulation phase
      • Fibroblasts migrate into site and secrete collagen
      • Wound is pink and vascular
      • Surface epithelium begins to regenerate
    • Maturation phase and scar contraction
      • Begins 7 days after injury and continues for several months/years
      • Fibroblasts disappear as wound becomes stronger
      • Mature scar forms

Secondary intention

  • Wounds that occur from trauma, ulceration, and infection have large amounts of exudate and wide, irregular wound margins with extensive tissue loss
  • Edges cannot be approximated
  • Results in more debris, cells, and exudate

Tertiary intention

  • Delayed primary intention due to delayed suturing of the wound
  • Occurs when a contaminated wound is left open and sutured closed after the infection is controlled

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