Opioid-Induced Disorders

Opioid-Induced Disorders 150 150 Tony Guo

Opioid-Induced Disorders

  • Intoxication
    • Symptoms are consistent with the half-life of most opioid drugs and usually last for several hours.
    • Symptoms include initial euphoria followed by apathy, dysphoria, psychomotor agitation or retardation, and impaired judgment.
    • Severe opioid intoxication can lead to respiratory depression, coma, and death.
  • Withdrawal
    • Dysphoria, muscle aches, nausea/vomiting, lacrimation or rhinorrhea, pupillary dilation, piloerection, sweating, abdominal cramping, diarrhea, yawning, fever, and insomnia.
    • From short-acting drugs (for example, heroin)
      • Symptoms occur within 6 to 8 hours, peak within 1 to 3 days, and gradually subside in 5 to 10 days
    • From long-acting drugs (for example, methadone)
      • Symptoms occur within 1 to 3 days, peak between days 4 and 6, subside in 14 to 21 days.
    • From ultra-short-acting meperidine
      • Symptoms begin quickly, peak in 8 to 12 hours, and subside in 4 to 5 days

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