Inflammatory Brain Disorder

Inflammatory Brain Disorder 150 150 Tony Guo

Inflammatory Brain Disorder

  • Most common inflammatory conditions of the brain and spinal cord
    • Brain abscesses
    • Meningitis
    • Encephalitis
      • 10% to 30% mortality rate
      • Long-term neurologic deficits among survivors

Bacterial meningitis

  • Acute inflammation of meningeal tissue surrounding brain and spinal cord
    • Usually occurs in fall, winter, or early spring
      • Often secondary to viral respiratory disease
  • Mandatory reporting to CDC
  • Mortality rate near 100% if untreated

Etiology and pathophysiology

  • Leading causes of bacterial meningitis
    • Streptococcus pneumoniae
    • Neisseria meningitidis
      • Replaced Hemophilus as flu vaccine emerged
      • Organisms enter CNS through upper respiratory tract or bloodstream
      • May enter through skull wounds or fractured sinuses
  • Inflammatory response
    • Increase CSF production
    • Purulent secretions spread to other areas of brain through CSF
    • Cerebral edema and increased ICP become problematic
      • If process extends into parenchyma
      • If concurrent encephalitis is present

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